生物医学中的细胞间和细胞间转移与通讯

English | 2024 | ISBN-10: 3031620356 | 586 pages| Epub PDF (True) | 32 MB

This volume covers recent developments on the role, composition, and functional significance of intercellular and interorganellar transfer. It highlights the involvement of intercellular and interorganellar transfer in cell and developmental biology, differentiation, pathogen dissemination, shaping the genetic makeup of organisms, and the development of various diseases. Animals and plants evolved different communication mechanisms and transfer of molecules and organelles between cells and between organelles within the individual cells. Tunneling nanotubes (TNTs) in animals, discovered as recently as 2004, and their functional equivalent in plants, plasmodesmata, discovered over 100 years ago, are the membranous bridges that mediate the transfer of organelles, membrane patches, vesicles, DNA/RNA, and different molecules between cells. In addition, there are other means of transfer and communication between the cells, such as cytonemes, airinames, extracellular vesicles (exosomes), and others. Variations in cytoskeletal composition, morphology, modality, and connected cells suggest that these structures play a role in development, establishment of cell fate, progenitor cell differentiation, cell reprogramming, ferroptosis, generation of cancer stem cells, and various diseases. The exchange of intact membrane patches (trogocytosis) between cells of the immune system may modify the immune response. Additionally, the transfer of genetic information between nucleus and organelles and cells of different species can shape the species and evolutionary outcome. Viral and bacterial pathogens can hijack the inter-cellular transfer routes to spread more efficiently. Cell-to-cell transfer of animal and plant pathogens can also occur by the virological synapse (VS). These specialized pathogen-induced structures share similarities and differences with neurological and immunological synapses.

英文|2024|ISBN-10:3031620356|586页|Epub PDF（真）|32 MB 本书涵盖了细胞间和细胞间转移的作用、组成和功能意义的最新进展。它强调了细胞间和细胞间转移在细胞和发育生物学、分化、病原体传播、塑造生物体的遗传组成以及各种疾病发展中的作用。动物和植物进化出不同的通讯机制，以及细胞之间和单个细胞内细胞器之间的分子和细胞器转移。最近在2004年发现的动物隧道纳米管（TNT）及其在植物中的功能等价物，即100多年前发现的胞间连丝，是介导细胞器、膜贴片、囊泡、DNA/RNA和细胞间不同分子转移的膜桥。此外，细胞之间还有其他转移和交流方式，如胞嘧啶、空气囊泡、细胞外囊泡（外泌体）等。细胞骨架组成、形态、形态和连接细胞的变化表明，这些结构在发育、细胞命运的建立、祖细胞分化、细胞重编程、脱铁、癌症干细胞的产生和各种疾病中发挥作用。免疫系统细胞之间完整膜斑的交换（吞噬作用）可能会改变免疫反应。此外，不同物种的细胞核、细胞器和细胞之间的遗传信息传递可以塑造物种和进化结果。病毒和细菌病原体可以劫持细胞间转移途径，更有效地传播。动物和植物病原体的细胞间转移也可以通过病毒学突触（VS）发生。这些由病原体诱导的特殊结构与神经和免疫突触既有相似之处，也有不同之处。

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