纳米颗粒在癌症疗法中的应用：创新与临床应用
This book presents the role of nanoparticles in cancer therapy, emphasizing their innovative applications across treatment, diagnosis and the development of therapeutic strategies. The first section of the book describes the applications of nanoparticles in cancer vaccines and gene therapy. It features discussions on polymeric nanoparticles as nanovaccine carriers, membrane-based nano-vaccines for immunotherapy and gene therapy techniques employing nanoparticles. The second section presents advanced nanomedicine approaches, specifying the role of chemodynamic nanoparticles in cancer theranostics, the application of low-dimensional nanomaterials and emerging strategies against drug resistance. Additionally, it explores nanotechnology in radiation therapy, phototherapy modalities and bioengineered virus-like nanoparticles for diagnostics and therapeutics. The last section reviews the clinical applications and prospects, examining theranostic nanoparticles, the clinical translation of nanomedicine and the current limitations of cancer nanotherapy. It also addresses future directions in nanoparticle application, and examines the genotoxicity, immunotoxicity, cytotoxicity assessments, safety profiles, targeted drug delivery, and their role in viral oncogenesis. This book is a useful resource for researchers, clinicians and students in the fields of oncology and nanotechnology.
这本书介绍了纳米颗粒在癌症治疗中的作用，强调了它们如何在治疗、诊断和开发治疗策略方面发挥创新性应用。本书的第一部分描述了纳米颗粒在癌症疫苗和基因疗法中的应用情况。其中包括聚meric纳米颗粒作为纳米疫苗载体的讨论、基于膜的纳米疫苗用于免疫疗法以及利用纳米颗粒进行基因疗法的技术。第二部分介绍了先进的纳米医学方法，具体说明了化学动力学纳米粒子在癌症疗剂中的作用、低维纳米材料的应用及对抗药耐性的新兴策略。此外，它还探讨了纳米技术在放疗、光疗技术和基于生物工程的病毒样纳米颗粒用于诊断和治疗方面的应用。最后一部分回顾了临床应用和前景，评估了疗剂型纳米粒子、纳米医学在临床上的应用以及癌症纳米疗法目前存在的局限性。同时，它也讨论了未来在纳米颗粒应用上的发展方向，并探讨了其基因毒性、免疫毒性和细胞毒性评估、安全性特征、靶向药物递送及其在病毒致癌中的作用。这本书对肿瘤学和纳米技术领域的研究人员、临床医生和学生来说是一个有用的资源。
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