当前及未来男性不育的进展

English | 2024 | ISBN-10: 3031626478 | 421 pages| Epub PDF (True) | 40 MB

Infertility is an important health problem affecting around 15% of couples worldwide, with profound psycho-social consequences and impairment of patients’ quality of life. It has been shown that the male factor is solely and partially implicated in 20-50% of the cases of infertility. Male infertility is a complex issue that can be related to a variety of congenital or acquired factors that lead to a decline in the quantity and/or the quality of semen. Over the recent years, there have been major advances in basic understanding of the factors that regulate male fertility, the diagnostic tests for assessment of male fertility potential, and the therapeutic options for the management of male subfertility/infertility. However, despite advances in technologies and diagnostic methods in the field of andrology, there remains a significant subset of these subfertile men who are classified as having unexplained or idiopathic male infertility. In addition, there are ongoing debates and controversies on the clinical management of infertile men under certain conditions like varicocele, genital tract inflammation/infection or non-obstructive azoospermia. This book discusses advances in cellular, molecular, and genetic aspects of spermatogenesis and sperm evaluation in the context of clinical scenarios. It also addresses clinical dilemmas and controversies through a discussion of the basic science underlying these conditions. The authors form an impressive international collaboration to provide a unique perspective that specializes in all key areas of andrology.

不孕不育是一个影响全球约15%夫妻的重要健康问题，它在心理社会方面造成深远的影响，并降低了患者的生存质量。研究表明，在不孕不育的病例中，男性因素单独和部分地参与了20-50%的情况。男性不育是一个复杂的议题，它可以与多种先天性或后天的因素相关联，这些因素导致精液数量和/或质量下降。近年来，我们在男性的生育调节因子、评估生育潜力的诊断测试以及治疗男性少子化/不孕症管理方面取得了重大进展。尽管在andrology领域科技和诊断方法方面取得了显著的进步，但仍然存在一个显著的亚群男性不育者被分类为具有不明原因或特异性的男性不育。此外，在某些条件下，如精索静脉曲张、生殖道炎症感染或无梗阻性无精子症的临床管理和治疗方面存在着持续的争议和分歧。 本书讨论了在临床情景下精子发生和精液评估方面的细胞学、分子学及基因层面的进步。同时也通过探讨这些疾病的基本科学原理来解决临床困境和争论问题。作者们组成了一个令人印象深刻的国际协作团队，以提供专注于andrology所有关键领域的独特视角。

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