《重编程大脑：脑和神经调控的未来指南》——一名患者和他的医生之作

English | 27 March 2024 | ISBN-10: 3031503988 | 179 pages| Epub PDF (True) | 28 MB

In June 2021, Doctor and Patient decided that time had come to surgically implant two six-inch-long metal alloy spikes all the way through Ben’s brain. It was felt that the medications Ben was taking to control his Parkinson’s disease had become unmanageable.

Back then, Ben was taking about 20 different pills a day. Each pill, if it absorbed properly, would activate the dopamine pathways in his brain and induce uncontrollable writhing movements that would last for about an hour. He would then get about 20 minutes where he’d feel somewhat normal before the slowness and tremor kicked in again. So, he’d take another pill and the cycle would repeat.

After months of adjusting his medication and finding just the right settings on his deep brain stimulator, it was decided, for the first time ever in a clinical trial in North America, to flip on the adaptive settings.

This is the story of how that decision was made and what happened next.

2021年6月，医生和患者决定是时候通过将两根六英寸长的金属合金针贯穿本大脑来外科植入手术了。感觉本帕金森病所服用的药物变得难以管理。 当时，本每天要服用大约20种不同的药片。如果每粒药片吸收正确的话，它会激活他大脑中的多巴胺路径并引发持续约一小时无法控制的扭曲运动。然后他会感到有一段时间是正常的，大约二十分钟，之后迟缓和颤抖又开始了。所以他就得再吃一颗药，循环继续。 在调整药物数月后，并找到自己深脑刺激器的最佳设置后，决定首次在北美临床试验中启用自适应设置。 这就是这个决定是如何做出的以及接下来发生了什么的故事。

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