神经调节代谢

English | EPUB (True) | 2018 | 239 Pages | ISBN : 9811312850 | 10 MB

This book systemically describes the mechanisms underlying the neural regulation of metabolism. Metabolic diseases, including obesity and its associated conditions, currently affect more than 500 million people worldwide. Recent research has shown that the neural regulation of metabolism is a central mechanism that controls metabolic status physiologically and pathophysiologically. The book first introduces the latest studies on the neural and cellular mechanisms of hypothalamic neurons, hypothalamic glial cells, neural circuitries, cellular signaling pathways, and synaptic plasticity in the control of appetite, body weight, feeding-related behaviors and metabolic disorders. It then summarizes the humoral mechanisms by which critical adipocyte-derived hormones and lipoprotein lipase regulate lipid and glucose metabolism, and examines the role of the hypothalamus-sympathetic nerve, a critical nerve pathway from CNS to peripheral nervous system (PNS), in the regulation of metabolism in multiple tissues/organs. Furthermore, the book discusses the functions of adipose tissue in energy metabolism. Lastly, it explores dietary interventions to treat neural diseases and some of the emerging technologies used to study the neural regulation of metabolism. Presenting cutting-edge developments in the neural regulation of metabolism, the book is a valuable reference resource for graduate students and researchers in the field of neuroscience and metabolism.

这本书系统地描述了神经系统调控代谢的机制。目前，代谢疾病如肥胖及其相关状况影响着全球超过5亿人。近期的研究表明，神经调控是通过生理和病理学方式控制代谢状态的核心机制。 本书首先介绍了下丘脑神经元、下丘脑胶质细胞、神经回路、信号传导途径以及突触可塑性的最新研究进展，这些对于食欲调节、体重大幅改变及与之相关的行为和代谢紊乱至关重要。接着总结了由关键脂肪细胞分泌的激素和脂蛋白酶调节脂质和葡萄糖代谢的内源性机制，并分析了下丘脑-交感神经这一从中枢神经系统（CNS）到周围神经系统（PNS）的关键神经路径在多个组织器官中调控代谢的作用。此外，本书还探讨了脂肪组织在能量代谢中的功能。最后，它探索了用于治疗神经疾病和一些新兴技术来研究神经调控代谢的研究方法。展示关于新陈代谢神经调控的前沿发展，本书是神经科学与代谢学领域研究生和研究人员的重要参考资源。

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