硫化氢在肾脏疾病中的应用：一种 novel 药物治疗手段

English | 2023 | ISBN-10: 3031440404 | 244 pages| PDF (True) | 9 MB

This book will be the first book that presents the beneficial effects of hydrogen sulfide in the treatment of various kidney pathologies. Hydrogen sulfide (H2S), a gas with a distinctive smell of rotten eggs, was known for over three centuries for its toxicity and death at high concentrations especially among agricultural and industrial workers. This is due to its ability to reversibly antagonize complex IV of the mitochondrial electron transport chain. However, studies over the past two decades have shown that H2S has risen above its historic notorious label and has received significant experimental attention as an endogenously produced gaseous signaling molecule that plays an important role in cellular homeostasis and influences a myriad of physiological and pathological processes at low concentrations. Its production is enzymatically regulated and has specific molecular targets. Several recent in vitro and in vivo studies have demonstrated that at low micromolar concentrations, H2S exhibits important therapeutic characteristics that target multiple molecular pathways and thereby preventing the development and progression of several pathologies. This beneficial effect of H2S suggests that it may meet the demand for alternative and/or additional therapeutic agents against various renal pathologies in which reduced levels of renal and plasma H2S were observed. Interestingly, while the distribution of H2S-producing enzymes is tissue-specific, they are abundantly expressed in the glomeruli and in the brush border and cytoplasm of epithelial cells of the renal tubules and in the peritubular capillaries. This makes the kidney a rich source of endogenous H2S production. From pre-clinical and clinical perspectives, this book is topical and timely, and seeks to lay the foundation for future clinical applications of H2S in nephrology.

这本书将是首次全面呈现硫化氢在治疗各种肾脏疾病中的益处的书籍。具有臭鸡蛋气味的硫化氢（H₂S）作为有毒气体，特别是在农业和工业工人中，在高浓度下会导致死亡，这一事实已经过去三个多世纪了。这归因于其能够可逆地拮抗线粒体电子传递链中的IV 复合物。然而，过去两十余年来的研究显示，H₂S已超越了它久远而臭名昭著的标签，并因其作为内源产生的气体信号分子在维持细胞稳态和影响一系列生理学和病理学过程中所起的重要作用，获得了显著的实验关注。其生产是酶促调控的，并具有特定的分子靶标。最近的一些体外和体内研究已经表明，在低微摩尔浓度下，H₂S表现出重要的治疗特性，这些特性针对多个分子途径并能防止多种病理的发展与进展。 硫化氢的这种益处暗示着它可能满足各种肾脏疾病中肾组织和血浆内H₂S水平降低的需求。有趣的是，虽然硫化氢生成酶的分布是组织特异性的，但它们在肾脏小管上皮细胞的滤泡和细胞质以及肾小球周围毛细血管中的表达量非常丰富。这使得肾脏成为内源性 H₂S 生产的一个富集来源。从临床前和临床的角度来看，这本书具有时效性和相关性，并致力于为硫化氢在未来在泌尿科领域的应用奠定基础。

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